In recent years, illicit drugs in the US have been cut with some high-profile and dangerous adulterants, such as the powerful veterinary sedative xylazine (aka tranq) and the yet more powerful veterinary sedative medetomidine. But last year, a new adulterant hit the streets. Unlike its predecessors, it didn't show up here and there and gain ground gradually; it seemed to show up everywhere at once and quickly overtook the market. Even more oddly, it's not a type of chemical one might expect in illicit drugs. It's not another sedative. In fact, it has no known psychoactive effects at all.

The chemical is bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, also called BTMPS, which is in a group of chemicals called hindered amine light stabilizers. BTMPS is usually added to plastics, coatings, and adhesives to protect them from weathering and UV radiation.

Researchers don't know why it's being added to illicit drugs—or what it does once it's there. BTMPS has never been tested in humans before given that it's never been intended for use in humans.

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If you were looking for some motivation to follow your doctor's advice or remember to take your medicine, look no further than this grisly tale.

A 64-year-old man went to the emergency department of Brigham and Women’s Hospital in Boston with a painful festering ulcer spreading on his left, very swollen ankle. It was a gruesome sight; the open sore was about 8 by 5 centimeters (about 3 by 2 inches) and was rimmed by black, ashen, and dark purple tissue. Inside, it oozed with streaks and fringes of yellow pus around pink and red inflamed flesh. It was 2 cm deep (nearly an inch). And it smelled.

The man told doctors it had all started two years prior, when dark, itchy lesions appeared in the area on his ankle—the doctors noted that there were multiple patches of these lesions on both his legs. But about five months before his visit to the emergency department, one of the lesions on his left ankle had progressed to an ulcer. It was circular, red, tender, and deep. He sought treatment and was prescribed antibiotics, which he took. But they didn't help.

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Medical organizations are blasting the Senate's budget bill in the wake of its narrow passage Tuesday, warning of the dystopian health care system that will arise from the $1.1 trillion in cuts to Medicaid and other federal health programs if it is passed into law. The bill has moved back to the House for a vote on the Senate's changes.

Over the weekend, an analysis from the Congressional Budget Office estimated that 11.8 million people would lose their health insurance over the next decade due to the cuts to Medicaid and other programs. Those cuts, which are deeper than the House's version of the bill, were maintained in the Senate's final version of the bill after amendments, with few concessions.

Organizations representing physicians, pediatricians, medical schools, and hospitals were quick to highlight the damage the proposal could cause.

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Scientists at several federal agencies are losing access to scientific literature published by Springer Nature, which produces the prestigious journal Nature among many other high-profile titles.

That's according to a report Monday by Nature's news team, which is also published by Springer Nature, but is editorially independent.

According to the news outlet, spokespeople for NASA and the US Department of Agriculture (USDA) confirmed that agency scientists would no longer have access to Springer Nature journals. A USDA spokesperson said that it "has cancelled all contracts and subscriptions to Springer Nature. The journal [sic] is exorbitantly expensive and is not a good use of taxpayer funds." A government spending database also shows the Department of Energy (DOE) has dropped contracts with the publisher.

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The US Supreme Court on Friday upheld a key provision of the Affordable Care Act that requires health plans to fully cover many preventive health care services recommended by a federal panel.

The ruling means that tens of millions of Americans can continue getting a variety of preventive services for free under their plans. Those cost-free services include an array of screenings, such as cancer screenings like mammograms and colonoscopies, as well as screens for obesity, lead exposure in children, high blood pressure, diabetes, and some sexually transmitted diseases, to name a few. The free services also include recommended vaccines for children and adults, well-baby and well-child doctor visits, birth control, statins, PrEP HIV prevention drugs, and fluoride supplements and varnishes for children's teeth.

The ruling stems from a lawsuit brought by a group of conservative Christians, represented by Braidwood Management, who objected to having to cover PrEP medication, which they claim can "encourage and facilitate homosexual behavior."

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Food poisoning is never fun—and a lot of the time, it can seem quite forceful. Take the common gut-buster norovirus for example. It can ignite forces that might make jet propulsion researchers jealous. Victims may fear liftoff from a porcelain launch pad, or a vomitous blast with a reverse thrust that seems powerful enough to drop a military jet from the sky.

But then there are the rare illnesses that produce truly violent forces. Such was the case for one unfortunate man in China who made the near-fatal decision to eat some dubious street food.

It's unclear what the 59-year-old ate exactly—but it's a safe bet he'll never eat it again. Soon after, his innards vigorously ignited. According to a case report in this week's issue of the New England Journal of Medicine, the man, in fact, vomited with so much explosive force that he blew apart his esophagus—the muscular tube through which food passes from the throat to the stomach.

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The vaccine panel hand-selected by health secretary and anti-vaccine advocate Robert F. Kennedy Jr. on Thursday voted overwhelmingly to drop federal recommendations for seasonal flu shots that contain the ethyl-mercury containing preservative thimerosal. The panel did so after hearing a misleading and cherry-picked presentation from an anti-vaccine activist.

There is extensive data from the last quarter century proving that the antiseptic preservative is safe, with no harms identified beyond slight soreness at the injection site, but none of that data was presented during today's meeting.

The significance of the vote is unclear for now. The vast majority of seasonal influenza vaccines currently used in the US—about 96 percent of flu shots in 2024–2025—do not contain thimerosal. The preservative is only included in multi-dose vials of seasonal flu vaccines, where it prevents the growth of bacteria and fungi potentially introduced as doses are withdrawn.

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After anti-vaccine advocate and US health secretary Robert F. Kennedy Jr. fired all 17 experts who sat on a revered federal vaccine panel and restocked it with eight dubious members, a growing chorus of lawmakers, health experts, and public advocates are calling for a pivotal meeting scheduled for Wednesday to be scrapped and for the panel to be "dissolved" and remade with qualified members.

On June 9, Kennedy unilaterally cleaned out the Centers for Disease Control and Prevention's Advisory Committee for Immunization Practices (ACIP). Though vetting for the committee has historically taken up to two years, Kenney announced the eight new members two days later. Some of the members are clear anti-vaccine activists, others have espoused contrarian or anti-public health perspectives, and some also have little to no relevant expertise for being on ACIP.

"[T]he reconstituted ACIP is a farce," Robert Steinbrook, a director at consumer rights watchdog Public Citizen, said in a statement. "Rather than further sullying the ACIP and undermining public confidence in vaccines, this week’s meeting should be rescheduled after the Senate has confirmed a new CDC Director who can both appoint an authoritative and representative committee and be able to approve the panel’s recommendations."

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About two months after receiving a donated kidney, a 61-year-old man ended up back in the hospital. He was tired, nauseous, and vomiting. He was also excessively thirsty and producing too much urine. Over the next 10 days, things only got worse. The oxygen levels in his blood began to fall. His lungs filled with fluid. He kept vomiting. He couldn't eat. Doctors inserted a feeding tube. His oxygen levels and blood pressure kept falling. He was admitted to the intensive care unit and put on mechanical ventilation. Still, things kept getting worse.

At that point, he was transferred to the ICU of Massachusetts General Hospital, where he had received the transplant. He was in acute respiratory failure and shock.

In a case report in this week's issue of the New England Journal of Medicine, doctors at Mass General explained how they determined what was wrong with the man. Their first steps were collecting more information about the man's symptoms from his wife, reviewing his family medical history, and contacting the regional organ-procurement organization that provided the kidney.

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President Donald Trump has supported use of asbestos in the past and blamed the mob for its bad reputation.

With ardent anti-vaccine activist Robert F. Kennedy Jr. in the country's top health position, use of a long-approved vaccine against measles, mumps, rubella, and varicella/chickenpox (MMRV) as well as flu shots that include the preservative thimerosal will now be reevaluated, putting their future availability and use in question. The development seemingly continues to vindicate health experts' worst fears that, as health secretary, Kennedy would attack and dismantle the federal government's scientifically rigorous, evidence-based vaccine recommendations.

Discussions of the two types of vaccines now appear on the agenda of a meeting for the Centers for Disease Control and Prevention's Advisory Committee for Immunization Practices (ACIP) scheduled for two days next week (June 25 and 26).

ACIP’s overhaul

On June 9, Kennedy summarily fired all 17 members of ACIP, who were rigorously vetted—esteemed scientists and clinicians in the fields of immunology, epidemiology, pediatrics, obstetrics, internal and family medicine, geriatrics, infectious diseases, and public health. Two days later, Kennedy installed eight new members, many with dubious qualifications and several known to hold anti-vaccine views.

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All 17 experts ousted from the federal vaccine advisory committee have spoken out about the drastic changes that anti-vaccine advocate and current US health secretary Robert F. Kennedy Jr. has made since taking office. Those changes include unilaterally restricting access to COVID-19 vaccines and summarily firing the entire Advisory Committee on Immunization Practices (ACIP), which had guided federal vaccine policies for more than 60 years.

"We are deeply concerned that these destabilizing decisions, made without clear rationale, may roll back the achievements of US immunization policy, impact people’s access to lifesaving vaccines, and ultimately put US families at risk of dangerous and preventable illnesses," the fired experts write in an editorial published in JAMA.

Kennedy dismissed the entire committee on June 9, accusing the former members of lacking public trust and being "plagued with persistent conflicts of interest," despite the committee's transparent disclosure and conflict of interest policies.

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Breast cancer. Colon cancer. An enlarged thyroid gland. A family history of tumors and cancers as well. It wasn't until the woman developed an annoying case of dry mouth that doctors put it all together. By then, she was in her 60s.

According to a new case study in JAMA Dermatology, the woman presented to a dermatology clinic in Spain after three months of oral unpleasantness. They noted the cancers in her medical history. When she opened wide, doctors immediately saw the problem: Her tongue was covered in little wart-like bumps that resembled a slippery, flesh-colored cobblestone path. (Image here.)

Such a cobblestone tongue is a telltale sign of a rare genetic condition called Cowden syndrome. It's caused by inherited mutations that break a protein, called PTEN, leading to tumors and cancers.

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Over 300 researchers from the National Institutes of Health have published a letter rebuking its director and the Trump administration for deep, politically motivated cuts to research funding, as well as disrupting global collaboration, undermining scientific review processes, and laying off critical NIH staff.

"We are compelled to speak up when our leadership prioritizes political momentum over human safety and faithful stewardship of public resources," the letter states, linking to independent news reports on the harms of NIH trials being halted and that the administration's cuts to the agency have cost, rather than saved, taxpayer money. Since January, the Trump administration has terminated 2,100 NIH research grants totaling around $9.5 billion and $2.6 billion in contracts, the letter notes. The researchers also accuse the administration of creating "a culture of fear and suppression" among federal researchers.

The letter describes the researchers' action as "dissent" from the administration's policies, quoting NIH Director Jay Bhattacharya in his congressional confirmation hearing as saying, "Dissent is the very essence of science."

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Notorious anti-vaccine advocate David Geier has begun working at the US Department of Health and Human Services and is seeking access to sensitive vaccine safety data that the Centers for Disease Control and Prevention had previously barred him from accessing—at least twice—according to reporting from The Wall Street Journal.

Geier and his father, Mark Geier, who died in March, are known for peddling the thoroughly debunked falsehood that vaccines cause autism, publishing a long list of dubious articles in low-quality journals that push the idea. In particular, the two have blamed the mercury-containing vaccine preservative, thimerosal, despite numerous studies finding no link. Thimerosal was largely abandoned from vaccine formulations in 2001 out of an abundance of caution.

In 2011, an investigation by the Maryland State Board of Physicians found that the Geiers were misdiagnosing autistic children and treating them with potent hormone therapies in a treatment they dubbed the "Lupron Protocol." Mark Geier was stripped of his medical license. David Geier, who has no medical or scientific background and holds only a bachelor's degree, was disciplined for practicing medicine without a license.

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Under the Trump administration, the Food and Drug Administration is eagerly embracing artificial intelligence tools that staff members are reportedly calling rushed, buggy, overhyped, and inaccurate.

On Monday, the FDA publicly announced the agency-wide rollout of a large language model (LLM) called Elsa, which is intended to help FDA employees—"from scientific reviewers to investigators." The FDA said the generative AI is already being used to "accelerate clinical protocol reviews, shorten the time needed for scientific evaluations, and identify high-priority inspection targets."

"It can summarize adverse events to support safety profile assessments, perform faster label comparisons, and generate code to help develop databases for nonclinical applications," the announcement promised.

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Exercise is generally good for you, but a new high-quality clinical trial finds that it's so good, it can even knock back colon cancer—and, in fact, rival some chemotherapy treatments.

The finding comes from a phase 3, randomized clinical trial led by researchers in Canada, who studied nearly 900 people who had undergone surgery and chemotherapy for colon cancer. After those treatments, patients were evenly split into groups that either bulked up their regular exercise routines in a three-year program that included coaching and supervision or were simply given health education. The researchers found that the exercise group had a 28 percent lower risk of their colon cancer recurring, new cancers developing, or dying over eight years compared with the health education group.

The benefits of exercise, published in the New England Journal of Medicine, became visible after just one year and increased over time, the researchers found. The rate of people who survived for five years and remained cancer-free was 80.3 percent among the exercise group. That's a 6.4 percentage-point survival boost over the education group, which had a 73.9 percent cancer-free survival rate. The overall survival rate (with or without cancer) during the study's eight-year follow-up was 90.3 percent in the exercise group compared with 83.2 percent in the education group—a 7.1 percentage point difference. Exercise reduced the relative risk of death by 37 percent (41 people died in the exercise group compared with 66 in the education group).

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This week, the US health department announced a plan to ban prescription fluoride supplements for children. These ingested fluoride products are dispensed at safe doses by doctors and dentists to prevent tooth decay in children who are unable to get adequate fluoride doses from community water systems—something that may become more common as more states and cities remove or ban fluoride from their water.

Both the American Dental Association (ADA) and the American Academy of Pediatrics recommend fluoridating community water and advise prescribing fluoride supplements for children who do not get adequate fluoride dosages through their water.

Nevertheless, the Department of Health and Human Services (HHS) under anti-vaccine advocate and conspiracy theorist Robert F. Kennedy Jr states without clear evidence that fluoride supplements harm children's microbiome and pose other health risks.

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News broke yesterday that researchers in Philadelphia appear to have successfully treated a 6-month-old baby boy, called KJ, with a personalized CRISPR gene-editing therapy. The treatment corrects an ultra-rare mutation in KJ that breaks a liver enzyme. That enzyme is required to convert ammonia, a byproduct of metabolism, to urea, a waste product released in urine. Without treatment, ammonia would build up to dangerous levels in KJ—and he would have a 50 percent chance of dying in infancy.

While the gene-editing treatment isn't a complete cure, and long-term success is still uncertain, KJ's condition has improved and stabilized. And the treatment's positive results appear to be a first for personalizing gene editing.

Now, who doesn't love a good story about a seemingly miraculous medical treatment saving a cute, chubby-cheeked baby? But, this story delivers more than an adorable bundle of joy; the big triumph is the striking timeline of the treatment's development—and the fact that it provides a template for how to treat other babies with ultra-rare mutations.

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With the abrupt withdrawal of the US, the World Health Organization is grappling with a brutal funding shortfall, leaving the United Nations health agency to slash top leadership and run global programs on a budget similar to that of a local hospital system.

In remarks at a budget committee meeting Wednesday, WHO Director-General Tedros Adhanom Ghebreyesus laid out the daunting budget numbers and announced a slimmed structure, cutting senior management from 14 to seven and the number of departments from 76 to 34.

"The loss of US funding, combined with reductions in official development assistance by some other countries, mean we are facing a salary gap for the next biennium of more than US$ 500 million," Tedros said.

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