Over 300 researchers from the National Institutes of Health have published a letter rebuking its director and the Trump administration for deep, politically motivated cuts to research funding, as well as disrupting global collaboration, undermining scientific review processes, and laying off critical NIH staff.

"We are compelled to speak up when our leadership prioritizes political momentum over human safety and faithful stewardship of public resources," the letter states, linking to independent news reports on the harms of NIH trials being halted and that the administration's cuts to the agency have cost, rather than saved, taxpayer money. Since January, the Trump administration has terminated 2,100 NIH research grants totaling around $9.5 billion and $2.6 billion in contracts, the letter notes. The researchers also accuse the administration of creating "a culture of fear and suppression" among federal researchers.

The letter describes the researchers' action as "dissent" from the administration's policies, quoting NIH Director Jay Bhattacharya in his congressional confirmation hearing as saying, "Dissent is the very essence of science."

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Notorious anti-vaccine advocate David Geier has begun working at the US Department of Health and Human Services and is seeking access to sensitive vaccine safety data that the Centers for Disease Control and Prevention had previously barred him from accessing—at least twice—according to reporting from The Wall Street Journal.

Geier and his father, Mark Geier, who died in March, are known for peddling the thoroughly debunked falsehood that vaccines cause autism, publishing a long list of dubious articles in low-quality journals that push the idea. In particular, the two have blamed the mercury-containing vaccine preservative, thimerosal, despite numerous studies finding no link. Thimerosal was largely abandoned from vaccine formulations in 2001 out of an abundance of caution.

In 2011, an investigation by the Maryland State Board of Physicians found that the Geiers were misdiagnosing autistic children and treating them with potent hormone therapies in a treatment they dubbed the "Lupron Protocol." Mark Geier was stripped of his medical license. David Geier, who has no medical or scientific background and holds only a bachelor's degree, was disciplined for practicing medicine without a license.

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Under the Trump administration, the Food and Drug Administration is eagerly embracing artificial intelligence tools that staff members are reportedly calling rushed, buggy, overhyped, and inaccurate.

On Monday, the FDA publicly announced the agency-wide rollout of a large language model (LLM) called Elsa, which is intended to help FDA employees—"from scientific reviewers to investigators." The FDA said the generative AI is already being used to "accelerate clinical protocol reviews, shorten the time needed for scientific evaluations, and identify high-priority inspection targets."

"It can summarize adverse events to support safety profile assessments, perform faster label comparisons, and generate code to help develop databases for nonclinical applications," the announcement promised.

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Exercise is generally good for you, but a new high-quality clinical trial finds that it's so good, it can even knock back colon cancer—and, in fact, rival some chemotherapy treatments.

The finding comes from a phase 3, randomized clinical trial led by researchers in Canada, who studied nearly 900 people who had undergone surgery and chemotherapy for colon cancer. After those treatments, patients were evenly split into groups that either bulked up their regular exercise routines in a three-year program that included coaching and supervision or were simply given health education. The researchers found that the exercise group had a 28 percent lower risk of their colon cancer recurring, new cancers developing, or dying over eight years compared with the health education group.

The benefits of exercise, published in the New England Journal of Medicine, became visible after just one year and increased over time, the researchers found. The rate of people who survived for five years and remained cancer-free was 80.3 percent among the exercise group. That's a 6.4 percentage-point survival boost over the education group, which had a 73.9 percent cancer-free survival rate. The overall survival rate (with or without cancer) during the study's eight-year follow-up was 90.3 percent in the exercise group compared with 83.2 percent in the education group—a 7.1 percentage point difference. Exercise reduced the relative risk of death by 37 percent (41 people died in the exercise group compared with 66 in the education group).

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This week, the US health department announced a plan to ban prescription fluoride supplements for children. These ingested fluoride products are dispensed at safe doses by doctors and dentists to prevent tooth decay in children who are unable to get adequate fluoride doses from community water systems—something that may become more common as more states and cities remove or ban fluoride from their water.

Both the American Dental Association (ADA) and the American Academy of Pediatrics recommend fluoridating community water and advise prescribing fluoride supplements for children who do not get adequate fluoride dosages through their water.

Nevertheless, the Department of Health and Human Services (HHS) under anti-vaccine advocate and conspiracy theorist Robert F. Kennedy Jr states without clear evidence that fluoride supplements harm children's microbiome and pose other health risks.

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News broke yesterday that researchers in Philadelphia appear to have successfully treated a 6-month-old baby boy, called KJ, with a personalized CRISPR gene-editing therapy. The treatment corrects an ultra-rare mutation in KJ that breaks a liver enzyme. That enzyme is required to convert ammonia, a byproduct of metabolism, to urea, a waste product released in urine. Without treatment, ammonia would build up to dangerous levels in KJ—and he would have a 50 percent chance of dying in infancy.

While the gene-editing treatment isn't a complete cure, and long-term success is still uncertain, KJ's condition has improved and stabilized. And the treatment's positive results appear to be a first for personalizing gene editing.

Now, who doesn't love a good story about a seemingly miraculous medical treatment saving a cute, chubby-cheeked baby? But, this story delivers more than an adorable bundle of joy; the big triumph is the striking timeline of the treatment's development—and the fact that it provides a template for how to treat other babies with ultra-rare mutations.

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With the abrupt withdrawal of the US, the World Health Organization is grappling with a brutal funding shortfall, leaving the United Nations health agency to slash top leadership and run global programs on a budget similar to that of a local hospital system.

In remarks at a budget committee meeting Wednesday, WHO Director-General Tedros Adhanom Ghebreyesus laid out the daunting budget numbers and announced a slimmed structure, cutting senior management from 14 to seven and the number of departments from 76 to 34.

"The loss of US funding, combined with reductions in official development assistance by some other countries, mean we are facing a salary gap for the next biennium of more than US$ 500 million," Tedros said.

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Since 2017, a particularly dangerous strain of E. coli O157:H7 has emerged across the country to spark outbreaks, severe disease, and deaths. It spreads in various ways: via leafy greens and contaminated beef, like its relatives, but also recreational waters. Hundreds of people across 46 states have been infected, and health officials have documented at least nine separate outbreaks. One in 2018, linked to lettuce, caused over 200 infections across 37 states, killing five people and causing a severe kidney condition in 26.

Now, a sweeping genetic analysis by researchers at the Centers for Disease Control and Prevention suggests a tiny mutation in one of the bacteria's molecular weapons may be behind the strain's rise. The finding, published recently in the journal Emerging Infectious Diseases, provides insights into this clinically significant plague and its rise to prominence. It also highlights the role of the bacteria's sophisticated military tactics.

The mutated weapon is part of a complex system that E. coli and other harmful bacteria sometimes use called a Type 3 Secretion System (T3SS). This involves molecular machinery that basically functions like a syringe, complete with a long needle that is poked into the cells of its victims. The T3SS then directly injects a fleet of hostile proteins. Those proteins—called effectors—attack specific targets that collectively disable the host's defense responses and make the host more hospitable for its bacterial conqueror.

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Far fewer babies went to the hospital struggling to breathe from RSV, a severe respiratory infection, after the debut of a new vaccine and treatment this season, according to an analysis published today by the Centers for Disease Control and Prevention.

RSV, or respiratory syncytial (sin-SISH-uhl) virus, is the leading cause of hospitalization for infants in the US. An estimated 58,000–80,000 children younger than 5 years old are hospitalized each year. Newborns—babies between 0 and 2 months—are the most at risk of being hospitalized with RSV. The virus circulates seasonally, typically rising in the fall and peaking in the winter, like many other respiratory infections.

But the 2024–2025 season was different—there were two new ways to protect against the infection. One is a maternal vaccine, Pfizer's Abrysvo, which is given to pregnant people when their third trimester aligns with RSV season (generally September through January). Maternal antibodies generated from the vaccination pass to the fetus in the uterus and can protect a newborn in the first few months of life. The other new protection against RSV is a long-acting monoclonal antibody treatment, nirsevimab, which is given to babies under 8 months old as they enter or are born into their first RSV season and may not be protected by maternal antibodies.

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Oncologist Vinay Prasad, a divisive critic of COVID-19 responses, will be the next top vaccine regulator at the Food and Drug Administration, agency Commissioner Martin Makary announced on social media Tuesday.

Prasad will head the FDA's Center for Biologics Evaluation and Research (CBER), which is in charge of approving and regulating vaccines and other biologics products, such as gene therapies and blood products.

"Dr. Prasad brings the kind of scientific rigor, independence, and transparency we need at CBER—a significant step forward," Makary wrote on social media.

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In a hard-to-watch video, a healthy-looking 4-year-old boy lies on a bed as doctors lift his eyelids to watch his big brown eyes erratically swirl and roll backward. His head jerks, and his little limbs weakly twitch and spasm. A small bit of foam pushes past his lips.

The video, captured by neurologists in India and published today in JAMA Neurology, shows what it looks like when the measles virus is allowed to ravage a child's brain. (The video can be viewed here.)

The boy was never vaccinated and developed a rare complication from measles called subacute sclerosing panencephalitis (SSPE). The condition occurs when the measles virus quietly sneaks into the central nervous system. It often lurks for years after an initial infection before it begins wreaking havoc, triggering damaging inflammation, destroying neurons, and causing brain lesions.

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Under President Trump, the Food and Drug Administration may no longer approve seasonal COVID-19 vaccines updated for the virus variants circulating that year, according to recent statements by Trump administration officials.

Since the acute phase of the pandemic, vaccine manufacturers have been subtly updating COVID-19 shots annually to precisely target the molecular signatures of the newest virus variants, which continually evolve to evade our immune responses. So far, the FDA has treated these tweaked vaccines the same way it treats seasonal flu shots, which have long been updated annually to match currently circulating strains of flu viruses.

The FDA does not consider seasonal flu shots brand-new vaccines. Rather, they're just slightly altered versions of the approved vaccines. As such, the regulator does not require companies to conduct lengthy, expensive vaccine trials to prove that each slightly changed version is safe and effective. If they did, generating annual vaccines would be virtually impossible. Each year, from late February to early March, the FDA, the Centers for Disease Control and Prevention, and the World Health Organization direct flu shot makers on what tweaks they should make to shots for the upcoming flu season. That gives manufacturers just enough time to develop tweaks and start manufacturing massive supplies of doses in time for the start of the flu season.

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As of Friday, April 25, the US has confirmed over 900 measles cases since the start of the year. The cases are across 29 states, but most are in or near Texas, where a massive outbreak continues to mushroom in close-knit, undervaccinated communities.

On April 24, the Centers for Disease Control and Prevention had tallied 884 cases across the country. Today, the Texas health department updated its outbreak total, adding 22 cases to its last count from Tuesday. That brings the national total to at least 906 confirmed cases. Most of the cases are in unvaccinated children and teens.

Overall, Texas has identified 664 cases since late January. Of those, 64 patients have been hospitalized, and two unvaccinated school-aged children with no underlying medical conditions have died of the disease. An unvaccinated adult in New Mexico also died from the infection, bringing this year's measles death toll to three.

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Climate tipping points pose grave risks to human health—and, unsurprisingly, approaching them while tipsy only makes the fallout more blistering, according to a case study in the New England Journal of Medicine.

In this week's issue, NEJM spotlights the effects of the climate crisis on clinical health with a series of case studies. One is the searing story of an inebriated gentleman who regrettably took a one-minute walk while barefoot during the unprecedented 2021 Northwest heat dome. The man walked across asphalt during the extreme weather, in which air temperatures reached as high as 42° C (108° F). That's about 21° C (38° F) above historical averages for the area.

Asphalt can absorb 95 percent of solar radiation and easily reach 40° F to 60° F above air temperatures on hot days. It's unclear how hot the asphalt was when the man walked across it, but it was clearly hot enough to melt some flesh.

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In now-rarified comments from experts at the Centers for Disease Control and Prevention, an agency official on Tuesday evening said the explosive measles outbreak mushrooming out of West Texas will require "significant financial resources" to control and that the agency is already struggling to keep up.

"We are scrapping to find the resources and personnel needed to provide support to Texas and other jurisdictions," said David Sugerman, the CDC's lead on its measles team. The agency has been devastated by brutal cuts to CDC staff and funding, including a clawback of more than $11 billion in public health funds that largely went to state health departments.

Sugerman noted that the response to measles outbreaks is generally expensive. "The estimates are that each measles case can be $30,000 to $50,000 for public health response work—and that adds up quite quickly." The costs go to various responses, including on-the-ground response teams, vaccine doses and vaccination clinics, case reporting, contact tracing, mitigation plans, infection prevention, data systems, and other technical assistance to state health departments.

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The rate of autism in a group of 8-year-olds in the US rose from 2.76 percent (1 in 36) in 2020 to 3.22 percent (1 in 31) in 2022, according to a study out Tuesday in the Morbidity and Mortality Weekly Report, a journal published by the Centers for Disease Control and Prevention.

The report's authors—researchers at the CDC and academic institutions across the country—suggest that the slight uptick is likely due to improved access to evaluations in underserved groups, including Black, Hispanic, and low-income communities.

The data comes from the CDC-funded Autism and Developmental Disabilities Monitoring (ADDM) Network. The national network has been tracking the prevalence of autism spectrum disorder (ASD) in 8-year-olds at a handful of sites since 2000, publishing estimates every two years. In 2000, ASD prevalence was 1 in 150, with white children from high-income communities having the highest rates of the developmental disability. In 2020, when the rate hit 1 in 36, it was the first year in which higher ASD rates were seen in underserved communities. That year, researchers also noted that the link between ASD and socioeconomic status evaporated in most of the network.

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European tourists who toted home bottles of water from a holy well in Ethiopia were likely hoping for blessings and spiritual cleansing—but instead carried an infectious curse and got an intestinal power cleanse.

Three people in Germany and four in the UK fell ill with cholera after directly drinking or splashing their faces with the holy water. Two required intensive care. Luckily, they all eventually recovered, according to a report in the journal Eurosurveillance.

The infections occurred in February after some of the patients reported taking independent trips to Ethiopia in January. Two of the German patients and three of the UK patients reported travel to the country, and several reported visiting a holy well called Bermel Giorgis (also spelled ‘Georgis’) in the Quara district. The German travelers and at least one of the UK travelers brought water home with them and shared it.

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Health experts took to one of the country's leading medical journals to pen searing rebukes of Robert F. Kennedy Jr.'s first weeks as the country's top health official—and they called upon their colleagues to rise up to fight the misinformation and distrust they allege Kennedy, a long-time anti-vaccine advocate, is fomenting.

From gutting federal health agencies and knee-capping critical local public health programs, to delaying a significant vaccine advisory meeting, hiring a discredited anti-vaccine advocate to conduct a vaccine study, ousting the country's top vaccine regulator, and undermining the response to the mushrooming measles outbreak in Texas that stands to threaten the country's measles elimination status—the researchers had no shortage of complaints.

In one article, pediatric infectious disease expert Kathryn Edwards of Vanderbilt University recounted the timeline of the measles outbreak, noting the missteps, missed opportunities, and controversial comments Kennedy made along the way. The rundown included his trivialization of the outbreak, failure to strongly advocate for vaccination, promotion of unproven treatments, like cod liver oil, and delayed responses from the Centers for Disease Control and Prevention, which Kennedy controls.

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It's well-established that, on the whole, Americans die younger than people in most other high-income countries. For instance, an analysis from 2022 found that the average life expectancy of someone born in Switzerland or Spain in 2019 was 84 years. Meanwhile, the average US life expectancy was 78.8, lower than nearly all other high-income countries, including Canada's, which was 82.3 years. And this was before the pandemic, which only made things worse for the US.

Perhaps some Americans may think that this lower overall life-expectancy doesn't really apply to them if they're middle- or upper-class. After all, wealth inequality and health disparities are huge problems in the US. Those with more money simply have better access to health care and better health outcomes. Well-off Americans live longer, with lifespans on par with their peers in high-income countries, some may think.

It is true that money buys you a longer life in the US. In fact, the link between wealth and mortality may be stronger in the US than in any other high-income country. But, if you think American wealth will put life expectancy in league with Switzerland, you're dead wrong, according to a study in the latest issue of the New England Journal of Medicine.

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Last week, Health Secretary and anti-vaccine advocate Robert F. Kennedy Jr. announced the Trump administration would hack off nearly a quarter of employees at the Department of Health and Human Services, which oversees critical agencies including the Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the Centers for Medicare and Medicaid Services (CMS).

The downsizing includes pushing out about 10,000 full-time employees through early retirements, deferred resignations, and other efforts. Another 10,000 will be laid off in a brutal restructuring, bringing the total HHS workforce from 82,000 to 62,000.

"This will be a painful period," Kennedy said in a video announcement last week. Early yesterday morning, the pain began.

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