Israel launched an expanded assault on Iran on Sunday, targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of deadly strikes.

The simultaneous attacks represented the latest burst of violence since a surprise offensive by Israel two days earlier aimed at decimating Tehran’s rapidly advancing nuclear program.

New explosions boomed across Tehran as Iranian missiles entered Israel’s skies in attacks that Israeli emergency officials said caused deaths around the country, including four in an apartment building in the Galilee region. A strike in central Israel killed an 80-year-old woman, a 69-year-old woman and a 10-year-old boy, officials said.

Casualty figures weren’t immediately available in Iran, where Israel targeted its Defense Ministry headquarters in Tehran as well as sites that it alleged were associated with the country’s nuclear program. Iran’s paramilitary Revolutionary Guard claimed that Iranian missiles targeted fuel production facilities for Israeli fighter jets, something not acknowledged by Israel.

Amid the continued conflict, planned negotiations between Iran and the United States over Tehran’s nuclear program were cancelled, throwing into question when and how an end to the fighting could come.

“Tehran is burning,” Israeli Defense Minister Israel Katz said on social media.

Both Israel’s military and Iran state television announced the latest round of Iranian missiles as explosions were heard near midnight, while the Israeli security cabinet met.

Israel’s ongoing strikes across Iran have left the country’s surviving leadership with the difficult decision of whether to plunge deeper into conflict with Israel’s more powerful forces or seek a diplomatic route.

Urgent calls to deescalate

World leaders made urgent calls to deescalate and avoid all-out war. The attack on nuclear sites set a “dangerous precedent,” China’s foreign minister said. The region is already on edge as Israel makes a new push to eliminate the Iranian-backed militant group Hamas in Gaza after 20 months of fighting.

Israel — widely believed to be the only nuclear-armed state in the Middle East — said its hundreds of strikes on Iran over the past two days have killed a number of top generals, nine senior scientists and experts involved in Iran’s nuclear program. Iran’s U.N. ambassador has said 78 people were killed and more than 320 wounded.

U.S. intelligence agencies and the International Atomic Energy Agency have repeatedly said Iran was not pursuing a nuclear weapon before Israel unleashed its campaign of airstrikes targeting Iran beginning Friday. But Iran’s uranium enrichment has reached near weapons-grade levels, and on Thursday the U.N.’s atomic watchdog censured Iran for not complying with obligations meant to prevent it from developing a nuclear weapon.

Prime Minister Benjamin Netanyahu, who has made the destruction of Iran’s nuclear program his top priority, said Israel’s strikes so far are “nothing compared to what they will feel under the sway of our forces in the coming days.”

In what could be another escalation if confirmed, semiofficial Iranian news agencies reported an Israeli drone struck and caused a “strong explosion” at an Iranian natural-gas processing plant. It would be the first Israeli attack on Iran’s oil and natural gas industry. Israel’s military did not immediately comment.

The extent of damage at the South Pars natural gas field was not immediately clear. Such sites have air defense systems around them, which Israel has been targeting.

Iran calls nuclear talks ‘unjustifiable’

The sixth round of U.S.-Iran indirect talks on Sunday over Iran ’s nuclear program will not take place, mediator Oman said. “We remain committed to talks and hope the Iranians will come to the table soon,” said a senior U.S. official, speaking on condition of anonymity to discuss diplomacy.

Iran’s top diplomat said Saturday the nuclear talks were “unjustifiable” after Israel’s strikes. Abbas Araghchi’s comments came during a call with Kaja Kallas, the European Union’s top diplomat.

The Israeli airstrikes were the “result of the direct support by Washington,” Araghchi said in a statement carried by the state-run IRNA news agency. The U.S. has said it isn’t part of the strikes.

On Friday, U.S. President Donald Trump urged Iran to reach a deal with the U.S. on its nuclear program, adding that “Iran must make a deal, before there is nothing left.”

US helps to shoot down Iranian missiles

Iran launched its first waves of missiles at Israel late Friday and early Saturday. The attacks killed at least three people and wounded 174, two of them seriously, Israel said. The military said seven soldiers were lightly wounded when a missile hit central Israel, without specifying where.

U.S. ground-based air defense systems in the region were helping to shoot down Iranian missiles, said a U.S. official who spoke on condition of anonymity to discuss the measures.

Israel’s main international airport said it will remain closed until further notice.

First responders were looking for survivors and clearing the remnants of a missile that fell on a neighborhood outside of Tel Aviv early Sunday morning.

An Associated Press reporter saw streets lined with damaged and destroyed buildings, bombed out cars and shards of glass.

Responders used a drone at points to look for survivors in some of the areas that were too hard to access. Some people were fleeing the area with their belongings in suitcases.

‘More than a few weeks’ to repair nuclear facilities

Israel attacked Iran’s main nuclear enrichment facility in Natanz. Satellite photos analyzed by AP show extensive damage there. The images shot Saturday by Planet Labs PBC show multiple buildings damaged or destroyed. The structures hit include buildings identified by experts as supplying power to the facility.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed. The main centrifuge facility underground did not appear to have been hit, but the loss of power could have damaged infrastructure there, he said.

Israel said it also struck a nuclear research facility in Isfahan, including “infrastructure for enriched uranium conversion,” and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

The International Atomic Energy Agency said four “critical buildings” at the Isfahan site were damaged, including its uranium conversion facility. “As in Natanz, no increase in off-site radiation expected,” it added.

An Israeli military official, speaking on condition of anonymity in line with official procedures, said that according to the army’s initial assessment “it will take much more than a few weeks” for Iran to repair the damage to the Natanz and Isfahan nuclear sites. The official said the army had “concrete intelligence that production in Isfahan was for military purposes.”

Israel denied it had struck the nuclear enrichment facility in Fordo, about 100 kilometers (60 miles) southeast of Tehran.

Among those killed were three of Iran’s top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard’s aerospace division, which oversees its arsenal of ballistic missile program, Gen. Amir Ali Hajizadeh. On Saturday, Khamenei named a new leader for the Revolutionary Guard’s aerospace division: Gen. Majid Mousavi.

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Israel attacked Iran’s capital early Friday in strikes that targeted the country’s nuclear program and killed at least two top military officers, raising the potential for an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran’s rapidly advancing nuclear program and appeared certain to trigger a reprisal, with Supreme Leader Ayatollah Ali Khamenei warning that “severe punishment” would be directed at Israel. Hours later, Israel’s military said it had begun intercepting Iranian drones launched in retaliation.

An Israeli official said the interceptions were taking place outside of Israeli territory, but did not elaborate. The official spoke on condition of anonymity pending a formal announcement.

Iraq said more than 100 Iranian drones had crossed its airspace, and a short time later neighboring Jordan said its air force and defense systems had intercepted several missiles and drones that had entered its airspace for fear they would fall in its territory.

Israel’s attack on Iran hit several sites, including the country’s main nuclear enrichment facility, where black smoke could be seen rising into the air. Later in the morning, it said it had also destroyed dozens of radar installations and surface-to-air missile launchers in western Iran.

The leader of Iran’s paramilitary Revolutionary Guard, Gen. Hossein Salami, was confirmed dead, Iranian state television reported, a development that is a significant blow to Tehran’s governing theocracy and an immediate escalation of its long-simmering conflict with Israel.

The chief of staff of Iranian armed forces, Gen. Mohammad Bagheri, was also confirmed dead by Iranian state television. Other top military officials and scientists were believed to have been killed.

In Washington, the Trump administration, which had cautioned Israel against an attack during continued negotiations over Iran’s nuclear enrichment program, said that it had not been involved and warned against any retaliation targeting U.S. interests or personnel.

Still, it seemed likely the U.S. suspected an attack could be in the offing, with Washington on Wednesday pulling some American diplomats from Iraq’s capital and offering voluntary evacuations for the families of U.S. troops in the wider Middle East.

Israel calls attacks preemptive strikes on Iran’s nuclear program

Israeli leaders cast the preemptive assault as a fight for the nation’s survival that was necessary to head off an imminent threat that Iran would build nuclear bombs, though it remains unclear how close the country is to achieving that or whether Iran had actually been planning a strike soon.

“It could be a year. It could be within a few months,” Prime Minister Benjamin Netanyahu said as he vowed to pursue the attack for as long as necessary to “remove this threat.”

“This is a clear and present danger to Israel’s very survival,” he said.

Israel is believed to have carried out numerous highly secretive attacks on Iranian soil over the years, though it has rarely acknowledged them. Most have been aimed at Iran’s nuclear program, though Iran has also accused Israel of targeting its natural gas pipelines and of assassinating Hamas political leader Ismail Haniyeh in Tehran.

Over the past year, Israel has also been targeting Iran’s air defenses, hitting a radar system for a Russian-made air defense battery in April 2024 and surface-to-air missile sites and missile manufacturing facilities in October.

Some 200 Israeli aircraft took part in Friday’s operation, hitting about 100 targets, Israeli army chief spokesman Brig. Gen. Effie Defrin said, adding that the attacks were ongoing.

In the aftermath, Defrin said Iran had launched more than 100 drones toward Israel and that “all the defense systems are acting to intercept the threats.”

Israel, Iraq, Iran and Jordan shut down their airspace to all flights as a precaution.

Iran confirms top officials and scientists killed

Khamenei issued a statement carried by the state-run IRNA news agency. It confirmed that top military officials and scientists had been killed in the attack.

Israel “opened its wicked and blood-stained hand to a crime in our beloved country, revealing its malicious nature more than ever by striking residential centers,” Khamenei said.

For Netanyahu, the operation distracts attention from Israel’s ongoing and increasingly devastating war in Gaza, which is now over 20 months old.

There is a broad consensus in the Israeli public that Iran is a major threat, and Israel’s opposition leader, Yair Lapid, a staunch critic of Netanyahu, offered his “full support” for the mission against Iran. But if Iranian reprisals cause heavy Israeli casualties or major disruptions to daily life, Netanyahu could see public opinion quickly shift.

Netanyahu expressed hope the attacks would trigger the downfall of Iran’s theocracy, saying his message to the Iranian people was that the fight was not with them, but with the “brutal dictatorship that has oppressed you for 46 years.”

“I believe that the day of your liberation is near,” the Israeli leader said.

Multiple sites in the Iranian capital were hit in the attack, which Netanyahu said targeted both nuclear and military sites. Also targeted were officials leading Iran’s nuclear program and its ballistic missile arsenal. The International Atomic Energy Agency confirmed that an Israeli strike hit Iran’s uranium enrichment facility at Natanz and said it was closely monitoring radiation levels.

The strike on Iran pushed the Israeli military to its limits, requiring the use of aging air-to-air refuelers to get its fighter jets close enough to attack. It wasn’t immediately clear if Israeli jets entered Iranian airspace or just fired so-called “standoff missiles” over another country. People in Iraq heard fighter jets overhead at the time of the attack. Israel previously attacked Iran from over the border in Iraq.

Tension had been growing for weeks ahead of attacks

The potential for an attack had been apparent for weeks as angst built over Iran’s nuclear program.

President Donald Trump on Thursday said that he did not believe an attack was imminent but also acknowledged that it “could very well happen.” Once the attacks were underway, the U.S. Embassy in Jerusalem issued an alert telling American government workers and their families to shelter in place until further notice.

U.S. Secretary of State Marco Rubio said Israel took “unilateral action against Iran” and that Israel advised the U.S. that it believed the strikes were necessary for its self-defense.

“We are not involved in strikes against Iran, and our top priority is protecting American forces in the region,” Rubio said in a statement released by the White House.

Trump is scheduled to attend a meeting of his National Security Council on Friday in the White House Situation Room, where he is expected to discuss the conflict with top advisers. It is not clear if he plans to make public remarks on the strikes.

Israel has long been determined to prevent Iran from developing nuclear weapons, a concern laid bare on Thursday when the Board of Governors at the International Atomic Energy Agency for the first time in 20 years censured Iran over its refusal to work with its inspectors. Iran immediately announced it would establish a third enrichment site in the country and swap out some centrifuges for more-advanced ones.

Even so, there are multiple assessments on how many nuclear weapons it could conceivably build, should it choose to do so. Iran would need months to assemble, test and field any weapon, which it so far has said it has no desire to do. U.S. intelligence agencies also assess Iran does not have a weapons program at this time.

In a sign of the far-reaching implications of the emerging conflict, Israel’s main airport was closed and benchmark Brent crude spiked on news of the attack, rising nearly 8%. Both Iran and Israel closed their airspace.

Israeli Defense Minister Israel Katz warned that in the aftermath of the strikes, “missile and drone attacks against Israel and its civilian population are expected immediately.”

“It is essential to listen to instructions from the home front command and authorities to stay in protected areas,” he said in a statement.

As the explosions in Tehran started, Trump was on the lawn of the White House mingling with members of Congress. It was unclear if he had been informed, but the president continued shaking hands and posing for pictures for several minutes.

Trump earlier said he urged Netanyahu to hold off on any action while the administration negotiated with Iran over nuclear enrichment.

“As long as I think there is a (chance for an) agreement, I don’t want them going in because I think it would blow it,” Trump told reporters.

This story was originally featured on Fortune.com

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